This isn't my car

But I should get one for our minivan, but Iris is definitely more the Wise than the Kiss kind.

I'm a finisher*

I suppose everyone has his/her Open Sesame, his/her Abracadabra or Presto Chango, the arbitrary word, event or unforeseen signal that knocks a person down, causes him/her to behave, either permanently or for the short term, out of the blue, contrary to expectation, from nowhere. A shade is pulled, a door creaks open, some kid goes from Geek to Glamour Boy. And Milton's Hocus-Pocus, his Master Key, happened to be a flowy sentence in Mr. Johnson's generic speech, a speech Dad would call "stirring as a wall of cinder blocke," indicative of the "Hallmark fever infecting our politicians and official spokesmen of late. When they speak, actual words don't emerge, but summer afternoons of draining sun and tepid breeze and chirping Tufted Titmice one would feel gleeful shooting with a handgun"

"When he said that thing about Hannah bein' like a flower," Milton said, "like a rose and all, I felt kinda moved." His big right arm lumber-rolled on top of the steering wheel as he edged the Nissan between the cars and out of the Student Parking Lot.

Special Topics in Calamity Physics goes on like this for 500 pages. You are either captivated by this type of gushing prose, or you are not. Why on earth I persisted, is a mystery. Actually, the book might have made a good 150 page mystery. I am the type that has to find out whodunit and I had to read it to the finish Final Exam.

All along the way, I wondered if Marisha Pessl was paid by the word or the pound. The first-person narrative by teenage genius, Blue Ver Meer, is just too precious. She paints mental images with words, accompanied by "visual aids" illustrations drawn by Blue/Marisha. The imagery is certainly vivid, but she and her editors never ask, "Is this image necessary?"

Pessl also hit my two pet peeves, the portrayal of Asian Americans and of modern physics in novels (for I cannot bear to call this book literature). Nearly all the characters are white, and there are plenty of insulting stereotypes to go around. But the portrayals of Asian Americans is particularly galling.

Character development for Blue's roommate at Harvard:

"You," said Soo-Jin, barely turning from Diagram 2114.74 "Amino Acids and Peptides" to hand me the phone.

and for a fellow high school classmate:

"I hope you're reincarnated as a mammal and our paths cross again, sooner rather than later because when I go to med school I doubt I'll have a life," wrote Lin Xe-Pen.

'Nuff said. What about the physics?

Whenever I heard an awful noise, one I couldn't identify, I told myself it was nothing but Chaos Theory, the Doppler Effect or the Heisenberg Uncertainty Principle applied to lost people in the dark. I think I repeated the Heisenberg Uncertainty Principle in my head at least one thousand times; the mathematical product of the combined uncertainties of concurrent measurements of position and momentum in a specified direction could never be less than Planck's constant, h, divided by 4 π. This meant, rather encouragingly, that my uncertain position and zero momentum and the Beast Responsible for the Sound's uncertain position and uncertain momentum had to sort of null each other out, leaving me with what is commonly known in the scientific world as "wide-ranging perplexity."

Huh? Read Heisenberg's own words.

IMHO Phillip Roth wrote the best use of physics imagery in literature I have ever read. Do you remember the line about the (white, lace) shiksa curtains? He described that fleeting moment each evening when glass becomes transparent (when the inside and outside light levels are roughly equal and the incidence angle of the light is less than Brewster's angle). In those few sentences, I could see the window, the curtains, the position of the sun and the yearning boy outside. I could even hear the sounds of dinner preparation inside.

Marisha Pessl is no Phillip Roth.

* One of my coworkers earned a PhD in engineering from CalTech while his wife pursued a PhD in Engligh Lit at UCLA. He told me that the piles of unfinished books around their house was driving him crazy. He didn't understand how she could start so many books and not finish them.

He called himself a finisher, a completer. Even when he didn't like a book, he felt compelled to finish it, just for the closure. He simply could not understand how she could put down book after book before the end. She never did complete her PhD dissertation and it bothers him more than it bothers her.

Anyway, this book taught me I am a finisher, too.

DNA Shuffle

A friend who suffers from a different auto-immune disorder was wondering how we can have both too much and too little immunity at the same time. I said something handwavy about lymphocytes gone bad. I learned in the November 2008 issue of Science Matters @ Berkeley that everyone makes bad lymphocytes, but healthy people destroy the bad ones before they can leave the bone marrow.

We rely on antibodies to recognize and sound the alarm on potential invaders. Yet our cells come programmed with less than 30,000 genes, far fewer than the billions of foreign structures we might encounter.

Even so, says Mark Schlissel, a Berkeley professor of immunology and pathogenesis, "the immune system is capable of recognizing literally hundreds of millions of foreign chemical structures."

This phenomenal flexibility comes courtesy of a remarkable DNA shuffling system called V(D)J recombination. Just as riffling a deck of cards can produce an endless variety of poker hands, shuffling specialized DNA segments in developing immune cells can produce a different antibody structure nearly every time. During the reaction, enzymes select one of many available genetic versions for each variable antibody segment, snip out the unused portions, and stitch the chosen pieces back together. The resulting antibody travels to the surface of the immune cell, or lymphocyte, where it can recognize bacteria, viruses and toxins in the bloodstream.

"All of us have developing lymphocytes in our bone marrow shuffling these antibody genes around continuously, from the time we are in the womb," Schlissel says. Schlissel studies V(D)J recombination and its place in lymphocyte development. Understanding when this reaction occurs and how it is regulated will help scientists learn to treat leukemia, lymphoma, immune deficiencies and a wide array of autoimmune diseases.
...
Every shuffle of DNA segments also carries the danger of producing an antibody that recognizes the body's own tissues. To avoid such potential autoimmune reactions, every new antibody undergoes self-tolerance testing in the bone marrow. If the antibody flunks, the recombinase returns to the nucleus for another round of gene rearrangement.

Read the rest of Doing the DNA Shuffle.